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- Human medicine
- Genetics, biochemistry and epidemiology of antimicrobial resistance
- Human medicine
- Genetics, biochemistry and epidemiology of antimicrobial resistance
Research priorities
- Study of the mechanisms of antimicrobial resistance in microorganisms that cause infections associated with health care and those acquired in the community.
- Study of antimicrobial resistance mechanisms in microorganisms recovered from animals and the environment.
- Epidemiological investigation of antimicrobial resistance in human health, animal health and environmental health.
- Biochemical analysis of proteins involved in antimicrobial resistance mechanisms.
EquipmentOngoing projectsScientific Publications
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Arturo Gonzales Rodríguez arturo.gonzales@udep.edu.pe Faculty of Human Medicine |
He holds a Bachelor's degree in Medical Technology with a specialization in Clinical Laboratory and Anatomical Pathology from the National University of San Marcos, and a Master's degree in Biochemistry from the same institution. He is currently a PhD candidate in Pharmacy and Biochemistry at the University of Buenos Aires. A professor and researcher with experience in microbiology and biochemistry, he has led research projects in molecular epidemiology, biophysics, and enzyme kinetics of proteins associated with antimicrobial resistance. In academia, he serves as Head of the Department of Biochemistry and Nutrition and teaches Microbiology at the Faculty of Human Medicine of the University of Piura. He has advised numerous theses and actively participated in interdisciplinary academic networks. He is a member of the American Society for Microbiology and the Argentine Association of Microbiology. |
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Edgar Gonzales Escalante edgar.gonzales@udep.edu.pe Faculty of Human Medicine |
Doctor of Microbiology from the Faculty of Pharmacy and Biochemistry, graduating with honors (Cum laude) from the University of Buenos Aires, Argentina. Medical Technologist specializing in Clinical Laboratory and Anatomy, and holds a Master's degree in Microbiology from the National University of San Marcos. He has experience in research, clinical practice, teaching, lecturing, and consulting on the implementation and organization of microbiology laboratories. His areas of interest include bacterial resistance, beta-lactamases, and clinical microbiology. |
| Project | Year | Project status | Description |
|---|---|---|---|
| Biochemical and structural characterization of AAC(6')-Ian and AAC(3)-lla | 2025 | In progress | Our previous studies have found the presence of the aac(6')-Ian and aac(3)-IIa genes in carbapenemase-producing Enterobacteriaceae isolates. These genes are associated with the expression of carbapenemases and extended-spectrum β-lactamases, as well as quinolone resistance. This scenario is alarming due to the pharmacological restrictions placed on patients, with the consequent use of highly toxic antibiotics such as colistin. Despite their potential impact on human health, there is no evidence regarding the biochemical and structural characteristics of AAC(6')-Ian and AAC(3)-IIa identified in circulating strains in our region. |
| Diversity and structure of IncC and IncF1B/HI1B plasmids in blaNDM-carrying Enterobacterales | 2023 | Completed | Antimicrobial resistance is a major threat to global public health due to its high prevalence and the resulting clinical and epidemiological consequences. Evidence suggests that the clonal spread of carbapenemase-producing Enterobacteriaceae (CPE) plays a critical role in hospital outbreaks of life-threatening infections, which have increased mortality, morbidity, and hospitalization costs. Therefore, it is relevant to determine the genetic diversity and structures of the IncC and IncF1B/HI1B plasmids in blaNDM-carrying Enterobacterales. |
| Epidemiology and in vitro activity of cefiderocol, ceftazidime/avibactam, aztreonam/avibactam and imipenem/relebactam against carbapenemase-producing Enterobacterales recovered from blood and urine samples of hospitalized patients during 2022 | 2023 | Completed | Antimicrobial resistance (AMR) is a public health problem that increases mortality rates, hospital stays, and consequently, the cost of hospitalization. Gram-negative bacilli are the main agents responsible for antimicrobial resistance, among which Enterobacterales are of greatest clinical importance. In recent years, an alarming increase in carbapenemase-producing Enterobacterales has been observed, and various regulatory agencies worldwide have approved new antimicrobials: cefiderocol, ceftazidime/avibactam, and imipenem/relebactam. However, several resistance mechanisms that inhibit their action have already been described. For this reason, we sought to evaluate in vitro the activity of these new antimicrobials in carbapenemase-producing Enterobacterales isolates recovered from blood and urine samples of hospitalized patients. |
| Molecular characterization of carbapenem-resistant enterobacterial uropathogens | 2022 | Completed | This study is focused on describing the phenotype and genotype of Enterobacteriaceae that resist carbapenems, the latter being a group of antibiotics used in the treatment of serious infections in humans. These bacteria are being isolated in urine samples from Peruvian patients. Our research will identify the genes that generate resistance to these powerful antibiotics. |
| Genomic analysis of Shigella sonnei carrying extended-spectrum beta-lactamase in Lima | 2022 | Completed | Shigella sonnei is a bacteria that causes diarrhea in the pediatric population. In addition, they have the ability to produce proteins that interrupt the action of various antibiotics. This phenomenon positions these bacteria as a public health problem. This study has identified some strains of these bacteria and is characterizing them from a molecular and genetic point of view. This way we can understand how in Peru these bacteria are generating their resistance genes. |
First report of KPC-35-producing Klebsiella pneumoniae ST258 isolated in Peru
Available in the Argentine Journal of Microbiology
Emergence of Shigella sonnei ST152 lineage III belonging to a high-risk clone carrying the blaCTX-M-15 gene in Peru
Available in the Argentine Journal of Microbiology
Identification of multi-resistant enterobacteria to antibiotics in stool samples from infants residing in Talara, Piura, Peru
Available in the Peruvian Journal of Experimental Medicine and Public Health
Extended spectrum β-lactamases and virulence factors in uropathogenic Escherichia coli in nursing homes in Lima, Peru.
Available in the Peruvian Journal of Experimental Medicine and Public Health
Immune and biochemical response of elderly people with urinary tract infection against virulence factors in Uropathogenic Escherichia coli
Available in the Peruvian Journal of Experimental Medicine and Public Health
From the Andes to the desert: 16S rRNA metabarcoding characterization of aquatic bacterial communities in the Rimac river, the main source of water for Lima, Peru
Available in PLoS ONE Magazine
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